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SIGHI Compatibility List

The Swiss Interest Group Histamine Intolerance's food compatibility guide: the most widely used practical dietary reference for histamine intolerance and MCAS in the international patient community. Foods organized into three tolerance tiers. Available in multiple languages. Use as a starting framework, not a rigid prescription, since individual tolerance varies significantly.

Maintz and Novak: Histamine and Histamine Intolerance (2007)

The foundational academic paper cataloguing foods by histamine content, histamine-releasing capacity, and DAO enzyme inhibition. The scientific basis underlying most dietary guidance for histamine intolerance. Useful to share with physicians who are unfamiliar with dietary histamine as a clinical variable.

The Low Histamine Chef

Yasmina Ykelenstam's extensive recipe and resource site for low-histamine cooking: one of the most practically useful dietary resources in this community. Recipes are organized by tolerance level and include whole foods that work for many MCAS patients. A good companion to the SIGHI list when translating the theory into actual meals.

Salt and Fluid Loading: Dysautonomia International Patient Guide

Dysautonomia International's patient-facing guidance on sodium and fluid loading for POTS, including specific target amounts, timing strategies, and the evidence behind them. The most credible freely available resource on this foundational management strategy. Always discuss with your physician before significantly changing sodium intake.

Seen. Symptom Tracker

Seen.'s own tracking tool, built specifically for people navigating POTS, MCAS, HSD, and migraine as a cluster. Designed to capture the interactions between conditions, generate physician-ready reports, and work from your phone without an app store download. Free during beta.

ChatDys: AI Assistant for Dysautonomia & Related Conditions

An AI chat platform trained on PubMed, peer-reviewed journals, and a curated knowledge base of nearly 7,000 condition-specific documents covering POTS, MCAS, EDS, dysautonomia, migraine, and adjacent conditions. Includes a symptom and health tracker, a living health roadmap, wearable and lab data integration, a community map connecting patients by location, and a genetics explorer for 150+ relevant SNPs. One of the most condition-literate AI tools available to this patient community. Free during beta. Not a substitute for medical care.

Visible

A pacing and energy management app designed specifically for ME/CFS and Long COVID, widely adopted in the POTS community. Uses heart rate variability data to help patients stay within their energy envelope and avoid post-exertional malaise. Particularly useful during reconditioning. Pairs well with the Seen. tracker for a more complete picture.

Bearable

A highly customizable symptom and health tracking app used widely in the chronic illness community. Not condition-specific, but its flexibility makes it adaptable for MCAS, POTS, and migraine tracking. Supports correlation analysis between symptoms, triggers, medications, and other variables.

Visible

A pacing and energy management app originally designed for ME/CFS that has been adopted widely in the POTS community. Uses heart rate variability data to help patients pace activity and avoid post-exertional malaise. Particularly useful during the reconditioning process.

Migraine Buddy

One of the most widely used migraine tracking apps: logs attacks, duration, severity, potential triggers, medications, and relief. Generates reports designed for neurologist appointments. Free tier is robust; premium adds deeper analytics.

Root Causes & Treatment of Mast Cell Disease (IFM Podcast with Dr. Lawrence Afrin)

An in-depth conversation with Dr. Lawrence Afrin, one of the physicians who helped define MCAS as a clinical entity, hosted by the Institute for Functional Medicine. Dr. Afrin discusses mast cell biology, why MCAS is so often missed, the limitations of standard testing, and the systems-level thinking required to identify and treat the condition. One of the clearest, most authoritative spoken-word resources available on MCAS. Particularly useful for patients preparing to discuss MCAS evaluation with a physician, or for sharing with care teams unfamiliar with the condition.

POTS Diagnosis and Treatment: A Guide for Physicians

A comprehensive physician education guide developed by Dysautonomia International. Covers POTS diagnostic criteria, subtypes, and evidence-based treatments. Free to download and share with your care team. One of the most useful documents to bring to a cardiologist or internist unfamiliar with POTS.

ME/CFS Primer for Clinical Practitioners

A clinical primer developed by the International Association for CFS/ME for healthcare providers. Covers diagnosis, management, and current research on ME/CFS. Particularly useful to share with primary care physicians or specialists who are seeing ME/CFS or Long COVID patients for the first time.

Dysautonomia International Patient Brochures

Free downloadable patient brochures covering POTS, MSA, PAF, NCS, and other dysautonomia conditions. Available in multiple languages. Clear, concise, and appropriate for sharing with family members, employers, or physicians who need a plain-language introduction to dysautonomia.

Hypermobile EDS and Migraine, National Headache Foundation

A clinical resource page from the National Headache Foundation explaining the connection between hypermobile Ehlers-Danlos Syndrome and migraine, written for patients and clinicians. Useful for patients trying to bring the connection to a headache specialist's attention, or for understanding why their migraine pattern may not respond to standard preventives until comorbid hypermobility is addressed.

Bateman Horne Center Patient Education Library

A library of patient education materials on ME/CFS, fibromyalgia, and Long COVID including videos, handouts, and webinar recordings. Produced by one of the leading clinical and research centers in this space. Quality is consistently high and the materials are designed to be shared with care teams.

NIH RECOVER Initiative

The NIH's national research program studying Long COVID and its overlap with POTS, ME/CFS, and other post-infectious conditions. Includes a patient registry, biorepository, and multiple clinical trials testing treatments for Long COVID symptoms. One of the largest and best-funded research efforts currently underway in this space. Open to patients with Long COVID and associated conditions.

ClinicalTrials.gov: POTS Studies

Search for active clinical trials studying POTS treatments, including new medications, exercise protocols, and device therapies. Filter by location and eligibility criteria to find trials you may qualify for. Updated continuously as new trials open.

ClinicalTrials.gov: ME/CFS Studies

Search for active clinical trials studying ME/CFS and Long COVID treatments, including NIH RECOVER initiative trials and independent research studies. Filterable by location, age, and eligibility. ME/CFS research is expanding rapidly and new trials open regularly.